The DNA cleavage and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 4-pyridinecarboxaldehyde with 4-aminopyridine
نویسنده
چکیده
The Schiff base complexes of Co(II), Ni(II) Cu(II) and Zn(II) have been synthesized from 4pyridine carboxaldehyde with 4-aminopyridine. They have been characterized by elemental analysis, molar conductance, molecular weight determination, IR, XRD and SEM. The metal in the Schiff base complex is hexa coordinated which binds through pyridine nitrogen, azomethine nitrogen and nitrate units of metal salt used in the preparation. The antimicrobial and cleavage activity have also been studied for the synthesized compounds. The Schiff base and its metal complexes show a good activity against the bacteria Staphylococcus aureus, E.coli, Klebsiella, Pneumonia and fungi like Candida albicans, Apergillus niger and Pencillium sp. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff base.
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